Enabling / disabling Microsoft NTFS for Mac by Tuxera is easy. You just need to navigate to:
System Preferences -> Microsoft NTFS by Tuxera -> General tab
If the software is disabled, after unlocking the lock with your administrator password you'll see the "Enable" button that you can activate. Also the Settings below are grayed out.
If the software is enabled and you want to disable the software globally, then you can unlock the lock with your administrator password and then select "Disable". This will disable Microsoft NTFS by Tuxera from your system and it won't be loaded at system startup.